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Zyban Sr (Bupropion)

Twenty percent of patients with cardiovascular disease smoke, and smoking cessation results in a dramatic decline in the relative risk of future cardiovascular events. There have been several randomized, controlled, clinical trials testing the safety of transdermal nicotine in patients with cardiovascular disease that failed to show an increased risk for cardiac events in active treatment conditions compared with placebo. Efficacy trials conducted in other patient populations also support the safety of nicotine-replacement use in cardiac disease patients. To date there is one randomized controlled trial to test Zyban Sr for smoking cessation conducted in this population. Nicotine-replacement therapy and bupropion significantly increase long-term smoking cessation rates, and the benefits of cessation exceed the risks for pharmacotherapy in patients with cardiovascular disease. Zyban Sr was developed for the treatment of depression, but subsequently was found to be effective for smoking cessation. Zyban Sr is an antidepressant that is structurally related to amphetamines and enhances dopamine neurotransmission through inhibiting neuronal dopamine re-uptake. Zyban Sr is an effective abstinence aid for cessation of smoking and possibly other drug use as well. There is evidence that Zyban Sr improves attention and impulse control in certain patient populations, and improvements in these processes could mediate its efficacy as an abstinence aid. Improvements in attention may contribute to the effectiveness of Zyban Sr as a pharmacotherapy for smoking. Although the proportion of the adult population in the United States that smokes has decreased steadily, the rate of successful quit attempts is still low. Smokers develop nicotine dependence that resembles other addictions, and may require multiple attempts and long-term treatment to sustain abstinence. Currently available first-line agents for smoking cessation therapy include nicotine replacement therapy, which is available in several formulations, including Zyban Sr. Physician advise, nicotine replacement therapy and Zyban Sr are all evidence based treatments that have success in increasing the likelihood of permanent smoking cessation. A basic understanding of the psychology of addictive behaviour is essential so that appropriate advice and treatment can be tailored to individual patients.

Smoking, the most prominent nongenetic factor contributing to mortality, remains the major public health problem throughout the world. There are nearly 1.1 billion users of nicotine and tobacco products worldwide while approximately one third to half of them will die from smoking-related disease. The habit of smoking is mainly propelled by nicotine, a strongly addictive substance, to which the vast majority of smokers fall victim. Except for the general and specific support and counseling strategies there are now effective treatments for nicotine addiction. Two types of pharmacological therapies have been approved and are now licensed for smoking cessation. The first therapy consists of nicotine replacement, substituting the nicotine from cigarettes with safer nicotine formulations. The second therapy is Zyban Sr, an antidepressant of the aminoketone class, which has been demonstrated to be effective in smoking cessation.

History

Bupropion was invented by Nariman Mehta of Burroughs Wellcome (now GlaxoSmithKline) in 1969, and the US patent for it was granted in 1974. It was approved by the United States Food and Drug Administration (FDA) as an antidepressant on December 30, 1985 and marketed under the name Wellbutrin. However, a significant incidence of seizures at the originally recommended dosage (400–600 mg) caused the withdrawal of the drug in 1986. Subsequently, the risk of seizures was found to be highly dose-dependent, and bupropion was re-introduced to the market in 1989 with a maximum recommended dose of 450 mg/day.

What is generic Zyban Sr?

Zyban Sr is a non-nicotine treatment that along with motivational support helps you to give up smoking. Zyban Sr is not a nicotine-replacement therapy. Zyban Sr contains 150 mg of the active ingredient bupropion hydrochloride, which is released slowly into the body. Zyban Sr also contains the following inactive ingredients: microcrystalline cellulose, hypromellose, cysteine hydrochloride monohydrate, magnesium stearate, macrogol 400, titanium dioxide (E171), carnauba wax and iron oxide black (E172).

Zyban Sr without prescription comes in foil blister strips, each containing 10 tablets and is available in a pack of 60 tablets.

What should I tell my health care provider before I take generic Zyban Sr without prescription?

Before you take Zyban Sr without prescription, it is very important to tell your doctor or pharmacist if you are taking any other medicines, either those prescribed by your doctor or those bought without a prescription.

These medicines include:

  • Medicines to treat depression (for example, amitriptyline, fluoxetine, paroxetine, desipramine, dothiepin or imipramine) or medicines to treat other psychiatric illness (for example, clozapine, risperidone, thioridazine or olanzapine)
  • Anti-malarial medicines (for example, chloroquine or mefloquine)
  • Tramadol, which is a strong painkiller
  • Theophylline, which is a medicine usually used to treat chest conditions such as asthma or lung disease
  • Steroids taken as tablets or injection (for example, prednisolone)
  • Some antibiotics belonging to a group called quinolones (for example, ciprofloxacin, nalidixic acid, levofloxacin, norfloxacin or ofloxacin)
  • Sedating antihistamines, which are medicines usually used to treat allergic reactions such as hay fever and can make you feel drowsy (for example, chlorpheniramine, diphenhydramine, cyclizine, trimeprazine or promethazine). They can also be used as sleep aids and for travel sickness
  • Slimming medicines or other stimulant medicines

Examples of other medicines that you are taking, which may increase the risk of side effects and are particularly important for your doctor or pharmacist to be aware of include:

  • Medicines usually used to treat epilepsy (for example, carbamazepine, phenobarbital, phenytoin or valproate)
  • Any nicotine-replacement therapy (do not use Zyban Sr without prescription and nicotine patches together, unless your doctor has told you to)
  • Beta-blockers (for example, metoprolol)
  • Medicines to treat abnormal heart rhythm (for example, propafenone or flecainide)

How should generic Zyban Sr without prescription be used?

Zyban Sr without prescription is a medicine that is used to help you stop smoking. You should not use it for any other purpose. You should start taking Zyban Sr without prescription while you are still smoking (it is not dangerous to smoke and use Zyban Sr without prescription at the same time) and set a "target stop date" for stopping smoking in the second week of treatment (e.g. Day 11). This is because Zyban Sr needs time to start working.

The usual dose for Zyban Sr without prescription is:

Take one tablet once a day for the first 6 days of your treatment course and then from Day 7, take one tablet twice a day for the rest of your treatment course. In some circumstances, for example, if you are taking certain medicines, if you are elderly, or if you have certain kidney or liver conditions, your doctor will tell you to take a lower dose of one tablet once a day throughout the whole course.

  • Swallow each tablet whole, with a drink of water. Do not crush, suck or chew the tablets
  • Do not take more than one tablet at any one time, and not more than two tablets in a day. Taking more than the prescribed dose will not improve your chances of stopping smoking successfully
  • Leave at least 8 hours between each dose
  • You may experience difficulty sleeping whilst taking Zyban Sr without prescription and this can be reduced by avoiding bedtime dosing (provided that there is at least 8 hours between each dose)
  • The treatment course should last between 7 to 9 weeks unless you experience a serious reaction to the medicine (see possible side effects of Zyban Sr without prescription)
  • Drinking of alcohol should be minimised or avoided during treatment as Zyban Sr without prescription may increase the effects of alcohol
  • Your doctor will ask you to stop taking Zyban Sr without prescription if you have not managed to stop smoking for a reasonable length of time by the seventh week of treatment
  • Your doctor may decide to reduce your dose gradually when stopping your Zyban Sr without prescription treatment
  • You should get as much help and support as possible while you are giving up smoking as this will increase your chances of succeeding
  • If you are using any other therapies to help you stop smoking, please ask your doctor or pharmacist for advice

What if I miss a dose?

If you forget to take a dose, take your next dose at the usual time. Do not take a double dose.

What may interact with generic Zyban Sr without prescription?

  • Medicines to treat Parkinson"s disease (for example, levodopa, amantadine or orphenadrine)
  • Tacrine which is a medicine used to treat Alzheimer"s disease
  • Pentazocine, which is a strong painkiller
  • Cyclophosphamide and ifosfamide, which are medicines mainly used to treat certain cancers Zyban Sr without prescription can cause dizziness and light-headedness, so it may affect your ability to perform tasks that need judgement.

What should I watch for while taking generic Zyban Sr without prescription?

Stop taking Zyban Sr without prescription and tell your doctor immediately should you, during treatment, experience any form of sudden collapse such as a faint, seizure (fit or convulsion) or blackout.

What side effects may I notice from generic Zyban Sr without prescription?

Giving up smoking can cause some effects (withdrawal symptoms) such as agitation; insomnia (difficulty sleeping), tremor and sweating which may be similar to some side effects associated with Zyban Sr without prescription and generally occur early during the treatment course. The more common side effects of Zyban Sr without prescription that could happen to more than 1 in 100 people taking it include:

  • Fever, dry mouth, constipation, tummy discomfort or upset, nausea (feeling of sickness) and vomiting
  • Skin rash or itching, including allergy reactions like nettle rash
  • Insomnia (difficulty sleeping), agitation, tremor and sweating
  • Difficulty concentrating (in rare cases this may include forgetfulness), headache, dizziness, feelings of depression (in rare instances this may include suicidal thoughts), anxiety
  • Changes in the taste of food or drink while you are taking Zyban Sr without prescription
Uncommon side effects that could happen to between 1 in 100 and 1 in 1,000 people taking Zyban Sr without prescription include:
  • Chest pain, feeling of weakness
  • Faster heartbeat than usual, increased blood pressure, flushing
  • Confusion, loss of appetite, ringing in the ears and disturbance of vision
Rare side effects that could happen to between 1 in 1,000 and 1 in 10,000 people taking Zyban Sr without prescription include:
  • Vasodilation (widening of the blood vessels) and fainting (especially on standing up)
  • Irritable or aggressive behaviour
  • Seizures (fits or convulsions)
  • Tingling or numbness (pins and needles)
  • Muscle spasm, tremor and inco-ordination
  • Palpitations (irregular or strong heartbeat)
  • Hallucinations (seeing, hearing, smelling, tasting or feeling things which are not really there)
  • Strange dreams, including nightmares
  • Depersonalisation (a feeling of being unreal or strange)
  • Severe allergic reactions (as described at the start of this section)
  • Jaundice (yellowing of the skin or the eyes) and hepatitis (inflammation of the liver)
  • Changes in blood sugar levels
  • Worsening of psoriasis
  • Urinating more or less than usual (passing water)
Very Rare side effects that could happen to less than 1 in 10,000 people taking Zyban Sr without prescription include:
  • Restlessness, aggression, delusions, paranoia.
If you experience any of these side effects or any other unusual effects after taking Zyban Sr without prescription, you must tell your doctor or pharmacist.

Where can I keep my medicine?

  • As with all medicines, it is important to keep Zyban Sr out of the reach and sight of children
  • Do not store Zyban Sr without prescription above 25°C. Store the tablets in the original pack
  • Do not use Zyban Sr without prescription after the expiry date printed on the carton or the foil blister strip.

Chemical names and formulas of Generic Zyban Sr

formula | C_13H_18ClNO name | bupropion IUPAC name | 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one alternate names | amfebutamone | bupropion HCl cheap Generic Zyban Sr without prescription

Chemical identifiers of Generic Zyban Sr

CAS number | 34841-39-9 PubChem CID | 444 PubChem SID | 178415 SMILES identifier | CC(NC(C)(C)C)C(=O)C1=CC(Cl)=CC=C1 isomeric SMILES identifier | C[C@H](NC(C)(C)C)C(=O)C1=CC(Cl)=CC=C1 InChI identifier | InChI=1/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 InChI key | SNPPWIUOZRMYNY-UHFFFAOYAJ DrugBank number | DB01156 LIMS drug number | 1156 KEGG drug number | D07591 KEGG compound number | C06860 ChEBI number | 3219 AHFS codes | 28:16.04.92 ATC codes | N07BA02 PharmGKB number | PA448687 Drug Product Database number | 02260239 cheap Generic Zyban Sr without prescription

Hydrophobicity and permeability properties of Generic Zyban Sr

experimental LogP hydrophobicity | 3.6 predicted LogP hydrophobicity | 3.28 predicted LogS | -3.54 cheap Generic Zyban Sr without prescription

Basic drug properties of Generic Zyban Sr

approval status | approved | small molecule drug categories | antidepressive agents | second-generation antidepressive agents | dopamine uptake inhibitors dosage forms | oral: tablet, extended release brand names | wellbatrin | wellbutrin | wellbutrin SR | wellbutrin XL | zyban cheap Generic Zyban Sr without prescription

Basic properties of Generic Zyban Sr

molecular weight | 239.7 g/mol monoisotopic molecular weight | 239.1 g/mol phase | solid cheap Generic Zyban Sr without prescription

Drug interactions of Generic Zyban Sr

Carbamazepine | Cyclosporine | Isocarboxazid | Phenelzine | Rasagiline | Rifabutin | Rifampin | Ritonavir | Thioridazine | Tranylcypromine cheap Generic Zyban Sr without prescription

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Disclaimer: Every effort has been made to ensure that the information provided by Online pharmacy without a prescription is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Copyright 2002-2009 Online pharmacy without a prescription. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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